Ginsenoside Rg1 effect on proliferation of spinal neurons

doi:10.3969/j.issn.2095-4344.2015.07.004

Abstract

Abstract:

BACKGROUND: Different neuroreceptors medicated by different receptors produce their own biological functions. The root cause of spinal cord injury is the death of neurons and the synaptic dysfunction. Ginsenoside Rg1 may play a protective role in neurons.

OBJECTIVE: To verify the nutritional and protective roles of ginsenoside Rg1 in spinal neurons of Sprague-Dawley rats.

METHODS: The spinal neurons were isolated from embryonic rats at a gestation age of 16 days, and following cryopreservation and resuscitation, the cells were divided into three groups: blank group, ginsenoside Rg1 group and positive control group (phenol solution). MTT method was used to detect the activity of mitochondria and ginsenoside Rg1 effects on the neuronal proliferation.

RESULTS AND CONCLUSION: Compared with the blank group, the cell absorbance value and cell relative activity were both higher in the ginsenoside Rg1 group, indicating that ginsenoside Rg1 can encourage the growth of neurons. When cells were intervened by ginsenoside Rg1, cell processes grew faster than those in the blank group, indicating ginsenoside Rg1 can protect the neurons, inhibit neuronal apoptosis, and boost the cell vitality.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Saponins, Neurons, Spinal Cord, Cell Proliferation

CLC Number:

R318

Sun Jian-zhong,Liu Xin-wei, Guan Hua-peng, Zhang Peng, Liu Qi, Yang Jun, Guo Qun-feng, Ni Bin. Ginsenoside Rg1 effect on proliferation of spinal neurons[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(7): 1003-1007.

Figures/Tables 5

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